Vinpocetine
Synonyms:
- 3a,16a-Apovincaminic acid ethyl ester
- (3a,16a)-Eburnamenine-14-carboxylic acid ethyl ester
- Ethyl apovincamin-22-oate
CAS: 42971-09-5
Molecular Formula: C22H27N2O2
Molecular Weight: 351.4614
Appearance: White to slightly yellow crystals or crystalline powder. Odorless
IR Identification: complies with reference standard
Specific Optical Rotation: between +127.0 and +134.0 (dried substance)
Loss on drying: ≤ 0.5%
Impurity A Ethyl Vincaminate: ≤ 0.6%
Impurity B Apovincamine: ≤ 0.5%
Impurity C Methoxyvinpocetine: ≤ 0.3%
Unspecified individual impurity: ≤ 0.1%
Total Impurities: ≤ 1.0%
Assay (on dry basis):
HCIO4 titration: between 98.5% and 101.5%
Heavy Metals: ≤ 10ppm
Residue on ignition: ≤ 0.1%
Residual solvents:
Ethyl-acetate: ≤ 1000 ppm
Microbiology:
Total bacterial count: < 1000 cfu/g
Fungi: < 100 cfu/g
Staphylococcus Aureus: Absent/g
Pseudomonas aeruginosa: Absent/g
Escherichia coli: Absent/g
Bile-tolerant Gram-Negative bacteria: < 100 cfu/g
Salmonella: Absent/10g
